IndraLab

Statements

TCR activates CYLD. 3 / 3
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"MALT1 proteolytic activity is induced upon TCR/CD28 costimulation, which promotes cleavage of the substrates BCL10, A20, CYLD, and RelB ( Coornaert et al., 2008 ; Hailfinger et al., 2011 ; Rebeaud et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with the primary screening, NF-kappaB reporter activity was similarly boosted upon TCR stimulation in USP34- and CYLD silenced Jurkat when compared to control non targeting siRNA transfected cells."
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"In addition, TCR stimulation in CYLD-deficient naïve T cells in vitro in the presence of TGF-β induces a marked increase in the number of Foxp3-expressing T cells."
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