IndraLab

Statements

USP2 activates Mice. 8 / 8
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"Moreover, increased USP2 expression reduced bone loss and enhanced osteogenic differentiation in OVX mice."
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"Taken together, these findings suggest the loss of USP2 promotes muscle loss and weakness in diabetic or DEX-induced mice."
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"Meanwhile, USP2 ablation-induced PD-L1 clearance enhances antitumor immunity in mice via increasing CD8 + T cells infiltration and reducing immunosuppressive infiltration of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), whereas PD-L1 overexpression reverses the tumor growth suppression by USP2 silencing."
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"In a transcriptome analysis of renal cortex comparing diabetic mice with diabetic post-menopausal mice, Usp2 expression was slightly enhanced in the menopause model [130]."
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"Correspondingly, infection with an adenovirus encoding Usp2 shRNA significantly lowered blood glucose, blood insulin, hepatic glycogen content, and insulin sensitivity in high fat diet–fed mice, suggesting that USP2 plays a role in aggravating T2DM pathogenesis [102]."
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"Indeed, USP2 inhibition alone partially induces tumor growth suppression but more strikingly, the combination of USP2 inhibition and PD-1/PD-L1 blockade promote vigorous tumor regression and long-term survival of all tumor-bearing mice."
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"Moreover, although a small-molecule inhibitor of USP2 alone can partially suppress the in vivo growth of p53-wild-type mammary tumor xenografts, more strikingly, USP2 inhibition and PD-1/PD-L1 blockade in combination promote vigorous tumor regression and long-term survival of all tumor-bearing mice."
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"Upregulation of USP2 reduces bone loss in OVX mice."
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