IndraLab

Statements

OTUB1 activates polyubiquitin chains. 4 / 4
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"Interestingly, OTUB1 preferentially induces cleavage of lysine 48 (K48)-linked polyubiquitin chains over K63-linked polyubiquitin chains (19)."
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"29 Intriguingly, OTUB1 preferentially targets polyubiquitin chains joined by K48-bonds."
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"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
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"28 For example, OTUB1 preferentially targets polyubiquitin chains joined by Lys48 bonds, while OTUB2 has specificity towards chains associated through Lys63."
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