IndraLab

Statements

USP28 inhibits MYC. 8 / 8
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"Thereafter, qRT‐PCR assays were performed on FBXW7, SKP2, USP28, and USP36, which confirmed that Dem could interact with FBXW7 and downregulate the expression of c‐Myc."
34766156
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"In addition, nickel and hypoxia exposure decreased USP28, a c-Myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-Myc ubiquitination and promoting c-Myc degradation."
21905451
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"In colon carcinoma, USP28 antagonizes the activity of the SCFFBW7 ubiquitin ligase complex to regulate the Myc stability and further promotes cell differentiation [XREF_BIBR]."
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"In addition, nickel and hypoxia exposure decreased USP28, a c-myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-myc ubiquitination and promoting c-myc degradation."
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"Furthermore, overexpressing USP28 inhibited FBXW7-185aa-induced c-Myc turnover (XREF_FIG)."
28903484
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"Moreover, FBXW7-185aa expression positively correlates with glioblastoma patient survival and negatively correlates with malignant phenotypes by inhibiting USP28-induced c-Myc stabilization (Yang et al., 2018)."
34342387
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"Moreover, circFBXW7 effectively inhibits glioma proliferation and cell cycle progression by antagonizing USP28 induced c-Myc stabilization [XREF_BIBR]."
32779638
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"FBXW7-185aa competitively interacts with USP28 and acts as a tumor-suppressive " decoy " that prevents USP28 binding to FBXW7alpha, thus antagonizing USP28 induced c-Myc stabilization."
28903484