IndraLab

Statements

USP28 inhibits MYC. 16 / 16
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"Degradation of c-MYC is inhibited by de-ubiquitination, and the ubiquitin-specific proteases USP28 and USP36 increase c-MYC stability by deubiquitination, protecting c-MYC from degradation ."
40000737
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"In colon carcinoma, USP28 antagonizes the activity of the SCFFBW7 ubiquitin ligase complex to regulate the Myc stability and further promotes cell differentiation [XREF_BIBR]."
30635654
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"In addition, nickel and hypoxia exposure decreased USP28, a c-Myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-Myc ubiquitination and promoting c-Myc degradation."
21905451
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"Loss of USP28 promotes MYC ubiquitination (45), predicting a diminished MYC-PAF1 interaction and enhanced expression of MYC target genes in USP28-deficient cells."
38227944
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"Thus, the peptide reduces the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization.In triple-negative breast cancer (TNBC), circ-FBXW7 produces the same above-mentioned protein (FBXW7-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33038492
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"Moreover, circFBXW7 effectively inhibits glioma proliferation and cell cycle progression by antagonizing USP28 induced c-Myc stabilization [XREF_BIBR]."
32779638
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"Moreover, FBXW7-185aa expression positively correlates with glioblastoma patient survival and negatively correlates with malignant phenotypes by inhibiting USP28-induced c-Myc stabilization (Yang et al., 2018)."
34342387
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"Thereafter, qRT‐PCR assays were performed on FBXW7, SKP2, USP28, and USP36, which confirmed that Dem could interact with FBXW7 and downregulate the expression of c‐Myc."
34766156
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"Such as the spanning junction open reading frame in circ-FBXW7 driven by internal ribosome entry site encodes a novel 21-kDa protein, which reduces the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization in mammals [12]."
38361078
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"Simultaneously, targeting USP28 promotes the degradation of c-MYC, resulting in cell cycle arrest and inhibition of DNA repair."
39222275
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"Furthermore, overexpressing USP28 inhibited FBXW7-185aa-induced c-Myc turnover (XREF_FIG)."
28903484
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"Therefore, while heterozygousity can destabilize MYC, complete deletion of USP28 triggers Fbw7 auto-destruction, resulting in the stabilization of Fbw7 substrates including MYC in specific tissues.106 Thus, the USP28-Fbw7α interplay dictates MYC stability and activity in the nucleoplasm and involves fine stoichiometry of the two opposing enzymes."
31832515
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"In the human gastric cancer cell line HGC-27, the level of USP28 decreases in a dose-dependent manner of compound 19, leading to the degradation of the substrate LSD1 and total c-MYC through the prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37245535
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"FBXW7-185aa competitively interacts with USP28 and acts as a tumor-suppressive " decoy " that prevents USP28 binding to FBXW7alpha, thus antagonizing USP28 induced c-Myc stabilization."
28903484
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"In addition, nickel and hypoxia exposure decreased USP28, a c-myc de-ubiquitinating enzyme, contributing to a higher steady state level of c-myc ubiquitination and promoting c-myc degradation."
20046830
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"FBXW7 circRNA encodes a novel 21-kDa protein, termed FBXW7-185aa, reduces USP28-mediated c-Myc stabilization [ 93 ], which may be associated to the Warburg effect."
30205139