IndraLab

Statements

CACNA1A activates hemiplegic migraine type 1. 5 / 5
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"Familial hemiplegic migraine type 1 (FHM-1) is caused by mutations in CACNA1A, the gene encoding for the Ca (v) 2.1 subunit of voltage gated calcium channels."
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"Familial hemiplegic migraine type 1 (FHM1, OMIM # 141500), caused by gain-of-function variants in CACNA1A, is an extreme type of migraine with aura that typically presents in the first or second decade of life with episodes of headaches, sensory loss, visual disturbance, hemiparesis, and cerebellar signs such as nystagmus or ataxia (Byers etal.,2016; Jen,2001)."
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"Familial hemiplegic migraine type 1 (FHM-1) is caused by mutations in the CACNA1A gene, with the R192Q mutation being the most common."
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"Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene."
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"Familial hemiplegic migraine type 1 (FHM1) is caused by mutations in the CACNA1A gene, encoding neuronal presynaptic Ca (V) 2.1 (P/Q-type) Ca (2+) channels."
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