IndraLab

Statements

CYLD inhibits Wnt. 7 / 8
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"Loss of function of CYLD, due to either mutation or deletion, can lead to dysregulated NF-κB and Wnt activity, promoting cell survival and proliferation.75 Studies have shown that CYLD mutations are associated with advanced stages of MM and may contribute to therapeutic resistance.75,123DIS3 is an RNA exosome component implicated in RNA processing and degradation."
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"In human cylindroma, CYLD negatively regulates Wnt and beta-catenin signaling via deubiquitination of Dishevelled, which is a key component in Wnt mediated beta-catenin nuclear translocation."
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"In addition, CYLD was proposed to inhibit Wnt signalling by deubiquitinating dishevelled XREF_BIBR."
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"CYLD negatively regulates NF-κB, WNT, and JNK signaling, and inactivating mutations can result in aberrant pathway activation, ultimately leading to enhanced cell proliferation, inhibition of apoptosi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It was also reported that loss of CYLD enhances Wnt/beta-catenin signaling through the K63-linked ubiquitination of Dvl ( Tauriello et al., 2010 )."
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"Increased CYLD expression may likewise diminish Wnt pathway activation and beta-catenin accumulation (XREF_FIG) via K63 linked deubiquitination of Dvl."
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"XREF_BIBR - XREF_BIBR Additionally, Tauriello et al XREF_BIBR demonstrated that CYLD inhibits the Wnt pathway by deubiquitinating disheveled in familial cylindromatosis tumors."
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