IndraLab

Statements

CYLD inhibits Wnt. 4 / 5
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"In human cylindroma, CYLD negatively regulates Wnt and beta-catenin signaling via deubiquitination of Dishevelled, which is a key component in Wnt mediated beta-catenin nuclear translocation."
22235375
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"Increased CYLD expression may likewise diminish Wnt pathway activation and beta-catenin accumulation (XREF_FIG) via K63 linked deubiquitination of Dvl."
23034333
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"XREF_BIBR - XREF_BIBR Additionally, Tauriello et al XREF_BIBR demonstrated that CYLD inhibits the Wnt pathway by deubiquitinating disheveled in familial cylindromatosis tumors."
33149672
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"In addition, CYLD was proposed to inhibit Wnt signalling by deubiquitinating dishevelled XREF_BIBR."
27561390