IndraLab

Statements

USP3 deubiquitinates Histone. 3 / 3
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"Notably, USP3 deletion increased the levels of histone ubiquitination in adult tissues, reduced the hematopoietic stem cell (HSC) reserves over time, and shortened animal life span."
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"Consistently, we found that USP3, which deubiquitylates H2A-type histones to prevent accumulation of RNF168 and downstream repair factors, but not RNF8, at DSB sites, also suppressed RNF169 recruitment in a manner requiring its catalytic activity (XREF_FIG)."
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"Overexpression of USP3 in HeLa cells reduced levels of both Ub-H2A and Ub-H2B, whereas knockdown of USP3 enhanced the ubiquitination of both histones."
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