IndraLab

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CCND1 activates USP22. 2 / 2

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"Strikingly, inhibiting downstream CCND1/CDK activity with PD-0332991 in USP22-overexpressing cells was sufficient to reverse the effect of USP22 on cell-cycle progression."

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"Levels of CCND1 in the cytoplasm decreased following depletion of either USP22 or USP2; however, both the chromatin-bound and chromatin-free pools of CCND1 were sensitive to USP22 depletion, while USP2 depletion had little effect on either pool."

30224477

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IndraLab

Statements

CCND1 activates USP22. 2 / 2

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