IndraLab

Statements

USP18 increases the amount of ISG. 4 / 4
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"Since USP18 iMacs also had increased STAT1 and STAT2 signaling, we wanted to determine if USP18 iMacs also had enhanced ISG expression after IFN‐β treatment."
29437254
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"Considering this finding, we hypothesized that USP18 may mediate atypical ISG expression by regulating transcriptional machinery beyond the canonical STAT2-ISRE interaction."
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"However, infection did interfere with the ISG regulatory IRF-STAT1 and STAT2 pathways to inhibit IFNT induced ISG expression including ISG15, HERC5, USP18 (involved in protein modification via ISGylation), DDX58, IFIH1 (cytosolic detection of viral RNA) and IFIT3, MX2, RSAD2, and SAMD9 (immune regulators with antiviral activity) XREF_BIBR."
32288965
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"Furthermore, UBA7/USP18 dKO cells remained sensitive to IFN and induced ISG expression at levels comparable to hUSP18 KO cells (Figures 5C and 5D).55 No significant differences in ISG induction or IFN sensitivity were observed between UBA7 KO cells and WT (Figures 5C and 5D)."
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