IndraLab

"Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic-activated K2P channel yet described."

"In the Xenopus oocyte and COS-7 cell expression systems, clinical doses of isoflurane, halothane, sevoflurane, and desflurane strongly increase TRESK currents up to three-fold by increasing the open probability [XREF_BIBR]."

"Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic activated K2P channel yet described."

"141516 The recently reported K channel is widely expressed in the central nervous system and regulates central neuronal excitability.3 TRESK currents are increased up to 3-fold by clinical concentrations of isoflurane, halothane, sevoflurane, and desflurane.17 TRESK also plays an important role in nociceptor excitability18 and in the pain pathway, therefore, TRESK is likely to be a major target of many volatile anesthetics and neuroprotective agents.Kang and Kim19 reported that the background K current of K channels in the DRG regulates DRG cell excitability; channel inhibition causes increased excitability."

"With both whole-cell voltage-clamp and patch-clamp recording, TRESK currents increased up to three-fold by clinical concentrations of isoflurane, halothane, sevoflurane, and desflurane."