IndraLab

Statements


USP18 inhibits USP18. 4 / 4
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"The overexpression of USP18 inhibited RANKL-induced osteoclast differentiation, while the knockdown of USP18 promoted that process, unveiling the inhibitory effect of USP18 in osteoclastogenesis."

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"The protein levels of ISG15 further depend on the levels of USP18, which itself was reduced in the NAC treated sample."

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"To investigate the mechanism of USP18-regulated DENV replication and its association with IFN, USP18 expression was attenuated by introducing USP18 small interference RNA (siUSP18) into cells."

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"The process can be reversed by the action of Ubiquitin Specific Peptidase 18 (USP18), a member of the deubiquitinase family which is the only ISG15-specific deubiquitinase enzyme that has been described so far [11]."