IndraLab

Statements

Brompheniramine inhibits KCNH2. 5 / 9
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"Brompheniramine tested in these experiments blocked hERG K + channels expressed in CHO cells in a concentration-dependent manner as displayed in Fig. 1 ."
17010640
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"Consistent with the previous study, our findings showed that brompheniramine concentration-dependently blocked the hERG channel with an IC 50 value of 0.90 ± 0.14 μM ( Fig. 1 ) and slightly prolonged [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17010640
trips
"Inhibition of HERG current by brompheniramine showed time-dependence."
17516459
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"Brompheniramine inhibited HERG current in a concentration dependent manner with the half-maximal inhibitory concentration (IC50) value of 1.7 microm at 0 mV."
17516459
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"These results indicate that brompheniramine mainly inhibited the HERG potassium channel through the residue Y652 and F656 and these residues may be an obligatory determinant in inhibition of HERG current for brompheniramine."
17516459