IndraLab

Statements



reach
"Consistent with the idea that dysregulated DNA repair promotes tumorigenesis [60], several studies have reported that aberrant expression of BRCC3 contributes to the progression or metastasis of several carcinomas, including pancreatic cancer [61] and gastric cancer [62] and represents a promising prognostic marker and a potential target in the therapies for these cancer types."

reach
"The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells."

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"In conclusion, BRCC3 promotes TNBC cell proliferation and metastasis by increasing the stability of ZEB1 under pathological conditions."