IndraLab

Statements

Testosterone inhibits STAT1. 4 / 4
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"Testosterone reduces inflammatory cytokine expression by downregulating the JAK and STAT1 signaling pathway."
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"In this study we investigated whether the testosterone reduces the prostatitis and related mechanism by regulating IFN-gamma and STAT1 signaling pathway."
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"Testosterone also downregulated directly the INF-gamma/JAK/STAT1 signaling pathway; especially, the mRNA levels of STAT1 and IFNG were reduced in cells treated with testosterone alone (XREF_FIG, p < 0.05, compared to the positive control)."
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"We also showed that testosterone can effectively suppress the activation of the JAK/STAT1 signaling pathway, thereby suppressing UPEC’s invasion of prostate cells and inducing an inflammatory response [27]."
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