IndraLab

Statements

USP12 increases the amount of ITGB1. 4 / 4
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"In contrast, re-expression of the catalytically inactive USP12 or USP46 mutants, in which the catalytic site cysteine was substituted for serine (Li et al, 2016; Yin et al, 2015), were unable to restore the Itgb1 levels indicating that USP12/46 require the DUB activity to maintain the 125 kDa mature Itgb1 levels (Figs."
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"Re-expression of USP12 in USP12/46-dKO or SNX17 in SNX17-KO fully restored the surface levels of Itgb1 (Fig. 3D)."
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"Co-expression of USP12 and SNX17 fully restored the Itgb1 levels in tKO fibroblasts, whereas separate expression of USP12 or SNX17 in tKO fibroblasts failed to normalize Itgb1 surface levels (Fig. 3D)."
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"Expression of USP12 in USP12/46-dKO fibroblasts rescued Itgb1 surface levels, whereas expression of USP12 or USP12 only partially rescued Itgb1 surface levels and expression of USP12 did not increase Itgb1 levels beyond the levels of USP12/46-dKO fibroblasts expressing EGFP-only (Figs."
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