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Modified USP3 leads to the deubiquitination of gammaH2AX. 2 / 2
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"In addition, while USP3 depletion resulted in delayed disappearance of ubiquitylaed H2A and FK2 staining (poly-ubiquitylation marker) after IR, over-expression of USP3 suppressed ubiquitylation of gam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Here, we showed that ectopic expression of USP3 led to the deubiquitination of both H2A and gammaH2AX in response to UV induced DNA damage."