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USP13 inhibits EGFR. 2 / 2

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"Moreover, USP13 inhibition and silencing lead to a decreased half-life of the mutant EGFR protein in NSCLC cells, indicating that USP13 likely stabilizes EGFR."

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"38, 39 Given that USP13 targeting caused EGFR destabilization, some of the effects may be independent of the EGFR kinase activity as EGFR can suppress cell death in manners that are independent of its kinase activity."

33210294

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IndraLab

Statements

USP13 inhibits EGFR. 2 / 2

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