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USP48 activates ARL3. 1 / 1
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"In agreement with the observed localisation of USP48 at synaptic sites [36] and plexiform layers in our immunostained retinal cryosections, USP48 might also be modulating the functions of UNC119a and ARL3, not only in the OS and cilium but in synapses too.Finally, over the past few years, there has been a growing interest in the development of small-molecule DUB inhibitors as therapeutic agents, mainly to treat cancer [66]."