IndraLab

Statements

BAP1 activates DNA replication. 5 / 5
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"BAP1 contributes to colon cancer cell proliferation by accelerating DNA replication and suppressing replication stress and concomitant apoptosis."
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"BAP1 depletion reduces colon cancer cell proliferation concomitant with increased apoptosis and defective DNA replication."
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"However, our previous work showed that the stability of Ino80 is regulated by the ubiquitin-proteasome system and that BAP1 functions as a deubiquitinase that stabilizes Ino80 and thus promotes DNA replication."
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"Therefore, it is unlikely that BAP1 contributes to the survival and proliferation of colon cancer cells via the Apc/β-catenin pathway.BAP1 functions in both normal DNA replication and replication stress recovery."
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"Our data instead showed that BAP1 depletion suppressed replication fork progression with concomitant induction of replication stress and apoptosis, suggesting that BAP1 promotes colon cancer cell proliferation by increasing the rate of DNA replication."
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