IndraLab

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OTUB2 activates Stroke. 3 / 3
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"Consistently, inhibition of OTUB2 with the small-molecule inhibitor LN5P45 attenuates ischemic stroke injury in mice and reduces neuronal death in human brain organoids after oxygen-glucose deprivation."

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"Furthermore, pharmacological inhibition of OTUB2 attenuated ischemic stroke injury in mice and neuronal death in human brain organoids."

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"However, after middle cerebral artery occlusion (MCAO), the infarct volume in Otub2 mice was significantly smaller than that of Otub2 mice (Fig. 1E,F), indicating that OTUB2 deficiency attenuates ischemic stroke injury."