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NKX2-5 increases the amount of SCN5A. 3 / 3
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"As development progress, the expression of NKX2-5, TBX5, MEF2c, ETV1, IRX3, and other transcription factors enhance the expression of Gja5/Cx40, Gja1/Cx43, and SCN5a (van Eif et al., 2018; Miquerol et al., 2010, 2011; Park and Fishman, 2017)."
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"Conditional deletion of Nkx2-5 after birth, decreased the expression of RyR2 and Nav1.5 channels and, thus, the I Na density in mouse cardiomyocytes, indicating that Nkx2-5 function is critical beyond[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Relatively rapid and progressive reduction of Na v 1.5 (alpha) expression in Nkx2-5 knockout hearts suggests that transcription of Scn5a may be directly regulated by Nkx2-5 in most ventricles."
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