IndraLab

Statements

USP9X leads to the deubiquitination of FBXW7. 4 / 4
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"USP9X inhibits FBXW7 autoubiquitination, thereby reducing the activity of its downstream substrate c-Myc and suppressing tumor formation in mice (Khan et al., 2018)."
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"USP9X antagonized FBW7 ubiquitylation and protected mice from CRC."
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"The deubiquitinase <span class="match term0">USP9X</span> regulates <span class="match term1">FBW7</span> stability and suppresses colorectal cancer"
29346117
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"USP9X antagonized FBW7 ubiquitylation, and Usp9x deletion caused Fbw7 destabilization."
29346117