IndraLab

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ATXN3 activates STUB1. 2 / 2

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"In MJD, these partnership are not only disrupted, but the presence of the expanded ataxin-3 now promotes clearance of both parkin and CHIP, which over time can have deleterious consequences on neurons in MJD and PD."

23653622

➶

reach

"CHIP levels are unaltered in ataxin-3 knockout mice, which suggests that when CHIP and ataxin-3 normally interact [133], this modulates CHIP activity within the ubiquitinating complex rather than mediating CHIP degradation [132]."

38497605

INDRA sources:

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IndraLab

Statements

ATXN3 activates STUB1. 2 / 2

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