IndraLab

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KCNK2 decreases the amount of BDNF. 3 / 3
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"XREF_FIG, we found that the knockdown of TREK-1 increased BDNF expression and that the over-expression of TREK-1 decreased the level of BDNF with increasing doses of isoflurane."
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"To our surprise, the knockdown of TREK-1 in astrocytes induced a significant increase in the expression of BDNF after treating with 2.4% isoflurane compared with expression in the vector group, but this increase was nonsignificant with the administration of 3.6%, possibly because the inhibitory effects of isoflurane at this high dose were so strong that the knockdown of TREK-1 could not rescue the expression of BDNF."
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"TREK-1 negatively regulated BDNF expression during isoflurane induced astrocytic toxicity."
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