IndraLab

"The calcium channel, voltage-dependent, alpha-2/ delta subunit 1 (CACNA2D1) gene encodes for a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel (VDCC) complex, which play an important role in muscle physiology."

"As indicated in xref , we also identified SNPs that showed the same direction of effect for schizophrenia and AD+P risk, Notable among these were two intronic SNPs located in CACNA1C , the gene encoding the voltage-dependent L-type calcium channel subunit alpha-1C. Although the genetic mechanism underlying these associations remains an area of active inquiry, xref convergent data suggests that schizophrenia is associated with reduced voltage-dependent calcium channel function. xref – xref How reductions in voltage-dependent calcium channel function may further increase AD+P risk is not known, however, impairments of intracellular Ca 2+ homeostasis are present in AD, and can contribute to synaptic dysfunction and cognitive impairments. xref "

"Key Words: brain ischemia, nimodipine, 1,4-DHP calcium channel antagonist receptors It is known that binding of 1,4-dihydropyridine (DHP) calcium channel antagonists to voltage dependent calcium chan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"VGCC-P/Q type antibodies are associated with two syndromes, namely, LEMS, and LEMS with paraneoplastic cerebellar degeneration ( Yamamoto et al., 2001 )."

"For example, MVIIC exhibits more severe side-effects than MVIIA, because MVIIC has higher binding ability to the P/Q type-calcium channel Cav2.1 than MVIIA ( Hillyard et al., 1992 )."

"Experiments with recombinant proteins were performed to map synaptic protein interaction sites on the alpha 1A subunit, which forms the pore of the P/Q-type calcium channel."

"Perry, D.C., H, Wei, R.E. Rosenthal and G. Fiskum, 1994, Autoradio- graphic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia/reperfu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Perry, D.C., Wei, H., Rosenthal, R.E. and Fiskum, G. (1994) Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral iscbemia/reper[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Voltage-dependent binding of dihydropyridine calcium channel blockers to guinea-pig ventricular myocytes."

"Epidemiological studies have shown that the use of L-type voltage-dependent calcium channel (L-VDCC) antagonists by patients with cardiovascular conditions is associated with a reduced incidence of AD in [ xref ] and patients treated with the L-VDCC antagonist nimodipine have improved cognitive scores compared to placebo-treated patients [ xref ]."

"For example, the light chains of the MT-associated protein 1B (LC1-MAP1B) and MT-associated protein 1A (MAP1A) interact with the presynaptic voltage dependent calcium channel Ca v 2.2 ( xref ; xref )."

"A membrane pathway for the binding of dihydropyridine calcium channel antagonists to the L-type calcium channel has been proposed by Rhodes and coworkers [23]."

"Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of mutation-specific episodic and chronic neurological disorders, including FHM with or without coma."

"These data are consistent with the view that aspect of the sleep-altering activity of triazolam involves interaction with voltage-dependent calcium channel activity."

"As a component of VGCC, Cav2.1 forms the pore region of the calcium channel and directs the channel activity ( xref )."

"BMP-7 also upregulated CACNA2D3, CACNB2, and CACNB4, the subunits of voltage-dependent calcium channel complex (Figure 5B)."

"Another possibility is that some mutations uniquely affect Best1’s ability to physically and functionally interact with voltage-dependent calcium channel subunits."

"Since VGCC-P/Q type antibodies have been reported in the absence of neurological disease, a LEMS diagnosis should be supported by electromyography findings ( Adams and Snutch, 2007 ; Fukuoka et al., 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"