IndraLab

"Key Words: brain ischemia, nimodipine, 1,4-DHP calcium channel antagonist receptors It is known that binding of 1,4-dihydropyridine (DHP) calcium channel antagonists to voltage dependent calcium chan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Perry, D.C., Wei, H., Rosenthal, R.E. and Fiskum, G. (1994) Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral iscbemia/reper[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"These data are consistent with the view that aspect of the sleep-altering activity of triazolam involves interaction with voltage-dependent calcium channel activity."

"A membrane pathway for the binding of dihydropyridine calcium channel antagonists to the L-type calcium channel has been proposed by Rhodes and coworkers [23]."

"Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of mutation-specific episodic and chronic neurological disorders, including FHM with or without coma."

"Experiments with recombinant proteins were performed to map synaptic protein interaction sites on the alpha 1A subunit, which forms the pore of the P/Q-type calcium channel."

"This activity stopped dendritic spine formation via L-type voltage-dependent calcium channel activity and protein synthesis."

"For example, the light chains of the MT-associated protein 1B (LC1-MAP1B) and MT-associated protein 1A (MAP1A) interact with the presynaptic voltage dependent calcium channel Ca v 2.2 ( xref ; xref )."

"Perry, D.C., H, Wei, R.E. Rosenthal and G. Fiskum, 1994, Autoradio- graphic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia/reperfu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Epidemiological studies have shown that the use of L-type voltage-dependent calcium channel (L-VDCC) antagonists by patients with cardiovascular conditions is associated with a reduced incidence of AD in [ xref ] and patients treated with the L-VDCC antagonist nimodipine have improved cognitive scores compared to placebo-treated patients [ xref ]."

"Another possibility is that some mutations uniquely affect Best1’s ability to physically and functionally interact with voltage-dependent calcium channel subunits."

"As indicated in xref , we also identified SNPs that showed the same direction of effect for schizophrenia and AD+P risk, Notable among these were two intronic SNPs located in CACNA1C , the gene encoding the voltage-dependent L-type calcium channel subunit alpha-1C. Although the genetic mechanism underlying these associations remains an area of active inquiry, xref convergent data suggests that schizophrenia is associated with reduced voltage-dependent calcium channel function. xref – xref How reductions in voltage-dependent calcium channel function may further increase AD+P risk is not known, however, impairments of intracellular Ca 2+ homeostasis are present in AD, and can contribute to synaptic dysfunction and cognitive impairments. xref "