IndraLab

Statements

Rcor1 binds USP22. 5 / 5
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"One of key requirements in this process seems to be the GSE1-dependent binding of USP22 to CoREST."
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"While loss of GSE1 does not affect the histone deacetylation activity of CoREST, GSE1 appears to be essential for binding of the deubiquitinase USP22 to CoREST and for the deubiquitination of H2B K120 in response to DNA damage."
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"Binding of USP22 to CoREST was independent of HDAC1 (Figure xref ) and also not affected by treatment with the HDAC inhibitor trichostatin A (TSA) ( xref )."
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"However, none of these interactions were observed in GSE1 KO cells, showing that GSE1 is indeed required for the binding of USP22 to the CoREST complex (Figure xref )."
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"Of note, we observed that GSE1 is essential for the binding of USP22 to CoREST, suggesting a role as a scaffolder."
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