IndraLab

Statements

C/VIF1 inhibits USP7. 8 / 8
| 8
reach
"Consequently, vif1 and vif2 peptides comprehensively suppress HAUSP activity, effectively restore p53 dependent apoptosis in wild-type p53 carrying cancer cells, and suppress tumor growth in mouse xenograft models."
22056774
reach
"HAUSP regulates the activities of MDM2 and p53 by deubiquitination, while vif1 and vif2 antagonize HAUSP and promote p53 dependent apoptosis XREF_BIBR."
23816559
reach
"We then investigated whether the vif1 and vif2 peptides can inhibit HAUSP DUB activity against ubiquitinated substrates through substrate binding competition."
22056774
reach
"Comprehensive inhibition of HAUSP deubiquitinase activity by vif1 and vif2 peptides."
22056774
reach
"Hence, vif1 and vif2 peptides significantly suppressing HAUSP DUB enzymatic activity, ultimately leads to p53 mediated anti-cancer activity [XREF_BIBR]."
26077642
reach
"2.5.2 Vif1 and vif2 : Peptide inhibitors of HAUSP deubiquitinase (US20140073585A1)."
26077642
reach
"They further demonstrated that vif1 and vif2 peptides robustly suppress HAUSP DUB enzymatic activity, ultimately leading to p53 mediated anti-cancer activity [XREF_BIBR]."
26077642
reach
"Vif1 and Vif2 are protease inhibitors of USP7, which can regulate the anticancer effect that is mediated by p53 and have the potential to become molecular targeted drugs for the treatment of laryngeal carcinoma [98]."
36613989