IndraLab

Statements

C/VIF1 inhibits USP7. 7 / 7
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"Hence, vif1 and vif2 peptides significantly suppressing HAUSP DUB enzymatic activity, ultimately leads to p53 mediated anti-cancer activity [XREF_BIBR]."
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"HAUSP regulates the activities of MDM2 and p53 by deubiquitination, while vif1 and vif2 antagonize HAUSP and promote p53 dependent apoptosis XREF_BIBR."
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"They further demonstrated that vif1 and vif2 peptides robustly suppress HAUSP DUB enzymatic activity, ultimately leading to p53 mediated anti-cancer activity [XREF_BIBR]."
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"We then investigated whether the vif1 and vif2 peptides can inhibit HAUSP DUB activity against ubiquitinated substrates through substrate binding competition."
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"Consequently, vif1 and vif2 peptides comprehensively suppress HAUSP activity, effectively restore p53 dependent apoptosis in wild-type p53 carrying cancer cells, and suppress tumor growth in mouse xenograft models."
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"2.5.2 Vif1 and vif2 : Peptide inhibitors of HAUSP deubiquitinase (US20140073585A1)."
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"Comprehensive inhibition of HAUSP deubiquitinase activity by vif1 and vif2 peptides."
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