IndraLab

Statements

MiRP1 activates KCNH2. 5 / 5
| 5
reach
"MiRP1 and Cterm-MinK modulated HERG much like wild-type MiRP1 (XREF_FIG C, right), suggesting that our chimera is indeed expressed and that it can not modulate KvLQT1."
10962015
reach
"The patient was found to harbour a KCNE2 gene mutation encoding a T10M amino acid substitution in MiRP1, an ancillary subunit that co-assembles with and functionally modulates hERG."
18006462
reach
"MinK associates with the KCNQ1 Kv channel alpha subunit to form the I Ks ventricular repolarization current in human heart; MiRP1 modulates the hERG alpha subunit which forms the cardiac I Kr repolarization current in human heart."
19219384
reach
"MiRP1 modulates hERG function and pharmacology, and MiRP1-hERG complexes may contribute to generating I Kr in human heart."
19219384
reach
"MiRP1 also modulates the response to external K + and, more importantly, MiRP1 appears to modulate the response of HERG K + channels to drugs 13,15 (see below)."
11339975