IndraLab

Statements

BAP1 activates EZH2. 3 / 3
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"Frequent loss-of-function mutations in epigenetic factors, such as ARID1A, SMARCA4, SMARCB1, BAP1, and KDM6A, are likely to elicit the EZH2 and PRC2 addicted situation."
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"In line with the observations in myeloid cells, Bap1 deleted mouse MM cell proliferation is impaired upon shRNA mediated down-regulation of Ezh2."
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"99 In addition, RCC derived cell lines deficient in BAP1 overexpress EZH2, and are sensitive to EZH2 inhibitors in vitro."
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