IndraLab

Statements

TNFAIP3 inhibits NLRP3. 8 / 8
| 8
reach
"The loss of function mutation in TNFAIP3, an inhibitor of NF-kB activation, in HA20 increased priming of NLRP3 inflammasome [30]."
33236284
reach
"High glucose culturing conditions increased TLR4 and NLRP3 proteins, which were also increased by TNFAIP3 siRNA."
35568203
reach
"Compared with LPS group, TA treatment significantly decreased the mRNA abundance of Bcl2l11, Nlrp3, interleukin-18 receptor 1 precursor (Il18r1), Traf5, Tnfaip3, Ccndbp1, Nfkbia, Casp1, and Cdkn1a whi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35617845
reach
"In mice, the overexpression of TNFAIP3 inhibits NLRP3 inflammasome complex, preventing lupus inflammation and renal injury ( 53 )."
37252693
reach
"On the other hand, TNFAIP3 overexpression significantly alleviates inflammatory responses and reduces activation of NF-κB and the NLRP3 inflammasome ( Li et al., 2015 )."
27640899
reach
"TNFaIP3 prevents the NFκB-dependent upregulation of NLRP3 and conversion of pro-IL1β to mature IL1β through the binding of its A20-like zinc finger domain to ubiquitin chains [52]."
38254713
reach
"In murine models, A20 and Tnfaip3 was shown to downregulate the activity of NLRP3 inflammasome."
28469620
reach
"The staining of NLRP3 positive clusters in CMECs transfected into Len-TNFAIP3 supports these data ( Fig. 7 J–K, P < 0.05), Indicating that the up-regulated TNFAIP3 inhibits NLRP3 activation and IL-1β [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33848581