IndraLab

Statements

NCIT:C94600 activates USP7. 3 / 3
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"Recently, it was observed that BCR-ABL activates the deubiquitinase HAUSP to promote phosphatase and tensin homolog (PTEN) delocalization in CML ( xref )."
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"Since FoxOs localization is also regulated by mono-ubiquitination [ xref ] and that BCR-ABL activates the FoxOs-deubiquitinase HAUSP [ xref ], it could be speculated that FoxOs nuclear localization could be affected by BCR-ABL/PML/HAUSP network in a similar manner as for PTEN [ xref ]."
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"Moreover, USP7 can stabilize BCR-ABL, therefore, USP7 and BCR-ABL might form a positive feedback in that USP7 stabilizes BCR-ABL, and BCR-ABL phosphorylates and activates USP7, therefore further promoting CML pathophysiology."
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