IndraLab

Statements

USP14 activates NLRC5. 4 / 4
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"USP14 deficiency significantly attenuates the inhibitory ability of NLRC5 on NF-kappaB activation, whereas the K1178R NLRC5 mutant showed similar inhibition of NF-kappaB activity in both WT and USP14 KO cells."
26620909
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"USP14 modulates NLRC5 function through its DUB activity."
26620909
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"Higher intrinsic USP14 levels in BMMs compared with BMDCs " forced " BMMs to move toward a state of higher USP14 values and subtly raised the sensitivity to NLRC5 in BMMs."
26620909
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"In contrast, ubiquitin specific protease 14 (USP14) specifically removes the polyubiquitin chains from NOD like receptor family CARD domain containing 5 (NLRC5) and thereby enhances the NLRC5 mediated inhibition of NF-kappaB signaling."
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