IndraLab

Statements


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"USP11 is able to modulate TNF-alpha-induced NF-kappaB activation through regulation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IkappaBalpha) stability."

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"However, down-regulation of USP11 dramatically enhances NF-kappaB activity in response to tumor necrosis factor-alpha, indicating that IKKalpha does not require activation of NF-kappaB."