IndraLab

Statements

ATP inhibits IKBKB. 4 / 4
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"Thus, earlier discovery efforts of pharmacological inhibitors of the NF-kappaB pathway were indeed aimed at developing ATP competitive inhibitors of IKK-2 activity [19,20]."
20176108
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"Taken together, these data suggest that the mechanisms of action of NBD peptides are distinct from those of ATP kinase inhibitors of IKK-2."
20167598
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"Pharmacological inhibition of NFkappaB p65 Serine (536) phosphorylation by SC-514, an ATP dependent competitive inhibitor of IKKbeta, significantly reduced p62 mRNA as well as protein levels in ARPE-19 cells under oxidative stress (XREF_FIG)."
28222108
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"Evaluation of small molecule ATP binding site inhibitors of IKKbeta re-inforces this concept although off-target side effects together with the compensatory activity of IKKalpha homodimers observed in the presence of IKKbeta inhibition may reduce their therapeutic efficacy XREF_BIBR, XREF_BIBR."
24798348