IndraLab

Statements

HUWE1 activates USP7. 2 / 2

| 1 1

sparser

"Conversely, under hypoxic conditions, USP7 is activated by the HECTH9 protein (polyubiquitination at K443 residue) and consequently stabilizes HIF-1α."

41157055

➶

reach

"Finally, as HIF-1alpha plays a major role in inducing tumor progression [XREF_BIBR], K63 polyubiquination of HAUSP mediated by HUWE1 would contribute to the oncogenic function of HUWE1."

30176860

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

HUWE1 activates USP7. 2 / 2

INDRA sources:

Databases

Reading