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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 increases the amount of CD274. 3 / 3

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"Indeed, CSN5 inhibition or gene silencing abolished PD-L1 expression and tumor proliferation in vivo."

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"showed that TNFa signaling resulted in increased expression of COP9 signalosome 5 (CSN5), a deubiquitinating enzyme, to enhance PD-L1 protein expression."

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"Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

COPS5 increases the amount of CD274. 3 / 3

Our Sources:

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