IndraLab

Statements

COPS5 increases the amount of CD274. 3 / 3
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"Indeed, CSN5 inhibition or gene silencing abolished PD-L1 expression and tumor proliferation in vivo."
29765155
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"showed that TNFa signaling resulted in increased expression of COP9 signalosome 5 (CSN5), a deubiquitinating enzyme, to enhance PD-L1 protein expression."
30197875
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"Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy."
27866850