IndraLab

Statements

COPS5 increases the amount of CD274. 11 / 12
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"Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy."
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"As presented in Fig. 9A, CSN5 overexpression decreased the phosphorylation of β-catenin but increased β-catenin and PD-L1 levels."
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"showed that TNFa signaling resulted in increased expression of COP9 signalosome 5 (CSN5), a deubiquitinating enzyme, to enhance PD-L1 protein expression."
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"Inhibition of Jab1 diminish cancer cell PD-L1 expression and sensitize cancer cells to anti-CTLA4 therapy [ 20 ]."
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"Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy ( Lim et al., 2016 )."
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"Indeed, CSN5 inhibition or gene silencing abolished PD-L1 expression and tumor proliferation in vivo."
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"In addition, inhibition of COPS5 by curcumin reduced the expression of PD-L1 and sensitized cancer cells to anti-CTLA4 treatment."
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"CSN5 facilitates tumor growth by inhibiting the degradation of Snail241, ZEB1242, surviving243 and FOXM1244, whereas curcumin-induced CSN5 depletion decreases PD-L1 expression and enhances the anticancer efficacy of anti-CTLA4 drugs245.Tumor-suppressive DUB families, CYLD lysine 63 deubiquitinase (CYLD) in the USP family and OTU deubiquitinase 1 (OTUD1) in the OTU family, constitute the second type of DUBs."
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"In addition, inhibition of Jab1/CSN5 by curcumin decreases the expression of PD-L1 and sensitizes cancer cells to anti-CTLA4 therapy ."
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"Inhibition of COPS5 by curcumin reduces the expression of PD-L1 in cancer cells, rendering them sensitive to CTLA4 therapy [7]."
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"The findings above demonstrate that CSN5 may not only promote the immune escape of PC cells by directly regulating PD-L1 expression but also increase the expression of PD-L1 by indirectly activating the β-catenin pathway.Collectively, we demonstrated that PDIA6 promoted the development of PC via 2 pathways."
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