IndraLab

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Curcumin activates COPS5. 3 / 3
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"Of note, CSN5 initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p 53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53 R273H."
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"CSN5 facilitates tumor growth by inhibiting the degradation of Snail241, ZEB1242, surviving243 and FOXM1244, whereas curcumin-induced CSN5 depletion decreases PD-L1 expression and enhances the anticancer efficacy of anti-CTLA4 drugs245.Tumor-suppressive DUB families, CYLD lysine 63 deubiquitinase (CYLD) in the USP family and OTU deubiquitinase 1 (OTUD1) in the OTU family, constitute the second type of DUBs."
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"Moreover, combination of Curcumin and anti-CTLA4 therapy enhanced the antitumor effects via inhibition of PD-L1 and COP9 signalosome 5(CSN5) compared to single treatment [ 223 ]."
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