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USP18 bound to interferon receptor inhibits JAK. 1 / 1

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"Interestingly, USP18 in humans (but not in mice) can also interfere with the anti-viral outcome of IFN signaling by an additional mechanism: USP18 can bind the interferon receptor 2 (IFNAR2), block the association of JAK, and possibly limit IFNAR2-IFNAR1 dimerization, thereby interfering with the JAK-STAT signaling pathway [89]."

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USP18 bound to interferon receptor inhibits JAK. 1 / 1

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