IndraLab

Statements

OTUB1 binds HIF and HTT. 4 / 4
| 4
sparser
"Taken together, our results demonstrate that FIH catalyses HD formation with OTUB1, which is remarkably sensitive to changes in oxygen availability within the physiologically relevant range, suggesting a function in oxygen-dependent signaling."
31299612
sparser
"Interestingly, purified FIH and OTUB1 did not form the HD under cell-free conditions (data not shown)."
31299612
sparser
"However, peptides corresponding to the suspected regions of FIH-OTUB1 HD formation could not be detected by MS, which is likely due to the unknown molecular weight of these unique peptides, and excludes a direct examination of the nature of the FIH-OTUB1 bond."
31299612
sparser
"The covalent FIH-OTUB1 HD formation may represent an alternative molecular mechanism for the cellular adaptation to oxygen changes over longer time periods, linking oxygen sensing and deubiquitinase activity."
31299612