IndraLab

Statements

Spautin-1 activates USP13. 9 / 9
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"Specifically, Spautin-1 promotes Beclin-1 degradation, by acting as an antagonist for two ubiquitin-specific peptidases, USP10/USP13, which are known to regulate Beclin-1 deubiquitination in Vps34 complexes."
37040770
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"Spautin-1 reportedly inhibits autophagosomal initiation and maturation by inhibiting deubiquitylases USP10 and USP13, which stabilize the Beclin-1 and VPS34 complex (26)."
33173007
reach
"The effect of nutrient deprivation on axonal maximal length was attenuated by the specific autophagy inhibitor Spautin-1, which prevents the deubiquitinating activity of USP10 and USP13 ( Liu et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33357422
reach
"The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism."
30618756
reach
"Spautin-1 has been recently reported to prevent autophagy by inhibiting the deubiquitinases USP10 and USP13, which leads to beclin 1 and Vps34 (or PI3KIII) degradation [XREF_BIBR]."
23421427
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"USP13 inhibitor, Spautin-1, treatment also impaired HR in control but not USP13 deficient cells (XREF_SUPPLEMENTARY)."
28569838
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"Spautin-1 reportedly suppresses autophagy by inhibiting the USP10 and USP13 deubiquitinases."
33547076
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"Spautin-1 targets the activity of two ubiquitin specific peptidases, USP10 and USP13 and causes PI3K complex degradation."
26993419
reach
"Spautin-1 promotes PINK1-PRKN-mediated mitophagy independent of USP10 and USP13.."
39051473