IndraLab

Statements

UCHL1 binds UCHL3 and Ubiquitin. 3 / 3
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"T218, R227, F228, and L230 residues of BAP1N were selected based on ubiquitin interaction with the corresponding residues of UCHL1 and UCHL3."
28935764
sparser
"In contrast with BAP1, the thermodynamics of ubiquitin binding to UCHL1 and UCHL3 is dominated by enthalpy factors and hydrogen bonding and ionic interactions that stabilize the complex."
28935764
sparser
"Unlike UCH-L1, UCH-L3 can interact with Lys48-linked Ub dimers (di-Ub) to protect it from degradation and meanwhile to inhibit its hydrolase activity."
20302916