IndraLab

Statements

OTUD5 inhibits SUPT16H. 5 / 5
| 5
reach
"Based on this and our results, we hypothesized that UBR5 and OTUD5 may temporarily antagonize the FACT activity to regulate the timely stalling and subsequent resumption of Pol II at the damage sites."
30508113
reach
"The FACT-limiting activity of OTUD5 is, at least in part, due to the recruitment and stabilization of the HDAC1 and HDAC2 proteins."
37713620
reach
"We have previously shown that the FACT histone chaperone, necessary for remodeling nucleosomes to allow for transcription, is negatively regulated by OTUD5 upon nuclease induction of DSBs (37)."
37713620
reach
"Thus, our work propose that FACT is an important factor in this in cis regulation, and that FACT is subject to regulation by OTUD5–UBR5 complex for the non-lesion stalling of Pol II.Our work leaves several open-ended questions; our data collectively suggest that OTUD5 and UBR5 repress FACT histone exchange activity, but how does this complex exactly achieve this?"
30508113
reach
"It is possible that OTUD5 prevents the FACT engagement on the histones or DNA, by directly binding to FACT."
30508113