IndraLab

Statements

Dofetilide increases the amount of KCNH2. 2 / 2
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"Dofetilide analogues that displayed high channel affinity, mediated by pi-pi stacks and hydrophobic interactions, also restored hERG protein levels, whereas analogues with low affinity were ineffective."
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"The increase in hERG surface expression by dofetilide is consistent with the increased trafficking efficiency observed by Varkevisser et al. (2013) XREF_BIBR."
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