IndraLab

Statements

Emodin inhibits NLRP3. 9 / 9
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"In summary, emodin treatment activates AMPK, suppresses NLRP3 inflammasome response, elevates antioxidant response, inhibits spinal inflammatory reaction and alleviates arthritis pain."
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"In this study, we hypothesized that emodin inhibited NLRP3 inflammasome activation via Nrf2 signaling."
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"Emodin might inhibit the cold-inducible RNA-binding protein (CIRP)-mediated activation of the NLRP3/IL-1β/CXCL1 signaling in rats, which then ameliorated the SAP-associated ALI (Xu et al., 2021)."
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"These, together with the effects of emodin, similar to C23, suggest that emodin may inhibit the activation of NLRP3 inflammasome by inhibiting the CIRP-induced NF-κB activation in resident macrophages."
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"In vitro , we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC , CASP1 , GSDMD , IL-1beta , and IL-18 ."
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"Taken together, our study showed that emodin inhibited NLRP3 inflammasome activation in vitro and LPS induced endotoxin shock in in vivo model."
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"In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1β, and IL-18."
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"Furthermore, emodin inhibited the P2X7 and NLRP3 signaling pathway followed by the decrease of pro inflammatory factors, and the latter is beneficial for the recovery of SAP."
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"Although the detailed mechanisms that link the common molecular pathways to the means by which emodin attenuates NLRP3 inflammasome activation remains to be elucidated, this is the first report providing scientific evidence substantiating the use of emodin in medicine for the treatment of various inflammatory diseases through the regulation of inflammasome activation, which may provide a valuable therapeutic strategy for controlling inflammasome mediated pathological conditions."
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