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DCPIB activates KCNK2. 9 / 9
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"Even more peculiar, DCPIB was found to enhance the activity of the two-pore domain K + channels TREK-1 and TREK-2, in their native environment and after recombinant expression [XREF_BIBR]."
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"DCPIB can activate TREK K channels in cultured astrocytes and increase basal K current in neurons in brain slices."
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"Recently DCPIB was found to activate TREK potassium channels in cultured astrocytes."
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"Moreover, DCPIB has been found to trigger K K channels, particularly TREK1, TREK2 and TRAAK (Minieri et al., 2013; Lv et al., 2019)."
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"However, besides blocking VRACs, we and others recently reported that DCPIB also modulated two-pore domain potassium (K2P) channels, namely, DCPIB activated TREK subfamily, while it inhibited TASK and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The present study also showed that DCPIB (10 μM) had no significant effect on endogenous Cl − channels in the LLC-PK1-αβ and HEK293-αβ cells.Recently, it has been reported that high concentrations of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"DCPIB, a known specific and potent inhibitor of volume regulated anion channels (VRAC), has been reported to activate TREK1 and TREK2 in astrocytes and in vitro recently."
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"However, we and others recently reported that DCPIB also potently modulated K2P channels, most interestingly, DCPIB was discovered to activate TREK subfamily, including TREK1, TREK2 and TRAAK channels[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, in the subsequent decades, it has been shown that DCPIB can also activate TREK channels in astrocytes ( Minieri et al., 2013 ), or it can also be a potent inhibitor of glutamate pathways in g[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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