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TEA inhibits KCNH1. 5 / 5
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"Both K + channel blockers, 4-AP and TEA, significantly inhibited the proliferation of Eag and HERG positive SK-OV-3 cells, confirming data by Zhanping et al., on the A2780 ovarian cancer line [XREF_BIBR]."
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"Both TEA and 4-AP are non selective K + channel blockers capable of inhibiting Eag and HERG as well as other voltage gated K + channels."
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"For example, several compounds including TEA + (tetraethylammonium ion), Quinidin, Chloroquine (CQ) and other potassium channel inhibitor drugs can inhibit Kv10.1 channels, but lack of specificity [29[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The block of Kv7.3 by linopirdine or XE991 was shown to increase the matrix mineralization in MG-63 cells [14], so the literature agrees that K channel inhibition leads to an increase in the mineral matrix formation.The concentration of astemizole used in our study (2 µM) was set to produce comparable inhibition of the hEag1 channels (~90%) to that of KCa1.1 channels by 1 mM TEA."
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"TEA blocks ~ 50% of the hEag1 current at 80 mV when present at 7 mM in the external solution or 200 muM in the internal solution (unpublished data)."
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