IndraLab

Statements

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits MAPK8. 44 / 93
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sparser
"SP600125 inhibits JNK1, JNK2, and JNK3 with a high specificity and markedly inhibits the activation/phosphorylation of c -Jun as well as expression of inflammatory genes xref ."
25428720
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No evidence text available
20146479
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No evidence text available
signor
"We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm)."
11717429
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"Alcohol activates JNK1 to upregulate transcription of Brf1 and Pol III genes, whereas inhibition of JNK1 by SP600125 or its siRNA significantly decreases the induction of these genes."
28552569
sparser
"SP600125 is an anthrapyrazolone capable of inhibiting JNK1, JNK2, and JNK3 with high affinity ( xref , xref )."
30444263
reach
"JNK1 activity was suppressed in rats by SP600125 treatment (XREF_FIG)."
27909723
tas
No evidence text available
25415535
reach
"SB, but not SP, was very effective in lowering the activation of p38 MAPK produced by AA plus 3-MA to below basal levels (XREF_FIG B and C; lanes 3 and 4) while SP, but not SB, effectively blocked the 2-3 fold elevated ratio of pJNK1 and JNK1 to below basal levels (XREF_FIG D and E : lanes 3 and 5), validating their specific inhibitory effectiveness."
24273738
reach
"The H 2 O 2 levels could be decreased by pcDNA3 (FLAG)-JNK1-wt transfection in A2780 and DDP cells and this effect could be counteracted by a JNK1 antagonist SP600125."
16105650
reach
"Importantly, inhibition of JNK1 by SP600125 blocked the reduction of apoptotic cell number (XREF_FIG) and apoptotic markers (i.e., cleavage of caspase-3 and PARP) caused by metformin (XREF_FIG)."
23223177
sparser
"SP600125 inhibits the JNK1, -2, and -3 pathways [ xref ]."
23861561
reach
"SP600125 inhibits the JNK1, -2, and -3 pathways [XREF_BIBR]."
23861561
tas
No evidence text available
18313304
reach
"SB203580 (an inhibitor of p38 MAPK; 10microM), PD98059 (an inhibitor of ERK2; 20microM), and SP600125 (an inhibitor of JNK1; 10microM) markedly inhibited p38 MAPK (XREF_FIG), ERK2 (XREF_FIG), and JNK1 (XREF_FIG) phosphorylation in collagen activated platelets, respectively."
29853830
tas
No evidence text available
21815634
sparser
"SP600125 is an anthrapyrazolone capable of inhibiting JNK1, JNK2, and JNK3 with high affinity [ xref ]."
26914092
sparser
"TGFβ also induced phosphorylation of (S351) NR4A1, JNK1, c-jun and c-fos which was also inhibited by SP600125, demonstrating that TGFβ induces JNK and genes downstream from JNK."
30072581
reach
"JNK1 can be inhibited by the anthrapyrazole SP600125 (XREF_TABLE), even though this compound also mildly impairs the function of p38beta and ERK2 [XREF_BIBR]."
26516076
sparser
"Since JNK-1 is required for the development of bone resorption activity by osteoclasts, the inhibition of bone resorption may be related to JNK-1 inhibition by SP600125 in vivo ."
20165551
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"In the present study, the Western blotting, IHC, and TTC staining results revealed that SP and D+YZR-0.8 g treatments effectively reversed the increased p-ASK1/ASK1 and p-JNK/JNK ratios, and the increased expression of TLR4, Iba1, GFAP, T3JAM, TRAF3, NF-κB, iNOS, COX-2, TNF-α, and IL-6 in the penumbral cortex and subsequently reduced the percentage of cerebral infarct areas and NDSs at 1 day after reperfusion."
34419138
reach
"Furthermore, inhibition of JNK1 by SP600125 promoted Epo withdrawal induced apoptosis (XREF_FIG)."
21095239
sparser
"SP600125 inhibits JNK1, JNK2, and JNK3 with similar potencies ( xref )."
18651635
reach
"A -smooth muscle cells were starved in serum-and growth factor-free medium for 18 h and then pretreated with SP600125 (SP) to inhibit JNK1 or PD98059 (PD) to inhibit MEK1 for 45 min."
18373239
reach
"TG-101348 (special JAK2 inhibitor, from MCE), JAK2 siRNA (sc-39099, from Santa Cruz Biotechnology), SP600125 (the inhibitor of JNK1, from Santa Cruz), and FR180204 (the inhibitor of ERK1, from Santa Cruz) were purchased."
33361763
reach
"We found that the up-regulated level of Netrin-1 and its receptor DCC promoted axonal regeneration and synaptic formation; the overexpression of Netrin-1 activated the JNK1 signaling pathway; these effects were partially reduced when JNK1 signaling pathway was inhibited by SP600125 (JNK specific inhibitor)."
29487502
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No evidence text available
18077363
reach
"As shown in XREF_FIG (MTT assay) and XREF_FIG (annexin-V and PI double staining), SP600125 (an inhibitor of JNK-1, -2 and -3), SB202190 (an inhibitor of p38 MAPK-beta), and U0126 (an inhibitor of MEK1/2) each significantly reduced glutamate induced cell death in a concentration dependent manner."
20542495
reach
"Additionally, in MPHs isolated from Jnk1 -/- and Jnk2 -/- mice, the response of nuclear RXRalpha to IL-1beta could only be inhibited by complete abrogation of JNK activation by pretreatment of SP600125 but not in the hepatocytes lacking each individual Jnk1 or Jnk2 gene (XREF_FIG)."
19767119
sparser
"As SP600125 inhibits both JNK1 and JNK2, to further evaluate the relationship between JNK2 and the UPR, BiP and CHOP were analyzed by western blot after JNK2 silencing."
23171849
reach
"The JNK specific inhibitor; SP600125 also inhibited JNK1 activation."
26928204
reach
"As SP600125 inhibits both JNK1 and JNK2, to further evaluate the relationship between JNK2 and the UPR, BiP and CHOP were analyzed by western blot after JNK2 silencing."
23171849
eidos
"Inhibition of Jun-N terminal kinase 1 ( JNK1 ) by ( A ) SP600125 and by ( B ) 3,6 - dihydroxyflavone ( 3,6 - DHF ) in an ADP-Glo kinase assay ."
25165860
sparser
"Importantly, inhibition of JNK1 by SP600125 blocked the reduction of apoptotic cell number ( xref ) and apoptotic markers (i.e., cleavage of caspase-3 and PARP) caused by metformin ( xref )."
23223177
reach
"Meanwhile, c-jun activity was significant attenuated by SP600125 or after transfection with the JNK1 siRNA in XREF_FIG."
22870247
reach
"Indeed, when Ubisol-Q -treated PSAF were treated with autophagy inhibitor SP600125 (a known inhibitor of beclin-1 via JNK1 inhibition [29, 30]), we saw a drastic decrease in autophagosome formation (Figures 4(a), 4(c), and 3) as well as the return of the SIPS phenotype (Figures 2, 3(a), and 3(b))."
31934268
reach
"SP600125 inhibits JNK1, JNK2, and JNK3 with similar potencies."
18651635
sparser
"Hence, inhibition of JNK1 and JNK2 by SP600125 reduces the expression of these transcription factors and cell cycle genes, thereby reducing cell proliferation."
24847381
sparser
"SP600125 inhibits JNK-1, JNK-2, and JNK-3 (cell-free IC 50 of 40 nM for JNK1 and 2, and 90 nM for JNK3). xref It has been shown that activated JNK isomers directly phosphorylate the BMAL1-CLOCK complex to regulate the speed and phase of circadian oscillations in cells; xref thus, treatment with SP600125 increased periods."
32493076
reach
"A -smooth muscle cells were starved in serum-and growth factor-free medium for 18 h and then pretreated with SP600125 (SP) to inhibit JNK1 or PD98059 (PD) to inhibit MEK1 for 45 min."
18373239
reach
"Furthermore, SP600125 was used to inhibit the potential downstream factor JNK1, and the osteogenic differentiation ability of DPSCs was evaluated."
30972205
reach
"SP600125, a potent JNK1 inhibitor, reduces the JNK1 activity associated with GLUT4 and the phosphorylation of two minor GLUT4 species in serum starved 3T3-L1 adipocytes."
18932217
reach
"JNK1 can be inhibited by the anthrapyrazole SP600125, even though this compound also mildly impairs the function of p38beta and ERK2 [XREF_BIBR]."
26516076
tas
No evidence text available
15711537