IndraLab

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USP9X activates apoptotic process. 28 / 29
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"In addition, the dephosphorylation of USP9X mediated by cell division cycle 14B (CDC14B) has previously been shown to promote mitotic apoptosis (72)."
37920433
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"Specific knock-down of Usp9X induces apoptosis in glioblastoma cells."
26872380
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"These results demonstrated that FAFs effectively induced apoptosis in the SGC-7901 cell line."
23251241
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"To correlate Tras-MMAE/FAM internalization with drug-induced apoptosis, cell viability was monitored using propidium iodide (PI) red fluorescence."
34522229
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"In the present study, we showed that FAFs induce apoptosis in the SGC-7901 cell line."
23251241
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"Expression levels of ARF-BP1 and Mule and Usp9x appears to be critical for the maintenance of proper cellular balance of anti- and pro apoptotic proteins, and contributes to cell sensitivity to apoptosis and is linked to tumor formation [XREF_BIBR, XREF_BIBR]."
21705204
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"siRNA knockdown of USP9X nearly completely suppressed apoptosis induced by cytokine treatment (XREF_FIG)."
26042473
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"Downregulation of FAF in the hypoxic myocardium decreases FGF9/FGFR2 signaling and increases apoptosis [80]."
39498345
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"In Fig. 4B , after incubation for 3 h, green FAM fluorescence in the cytoplasm appeared indicating the activation of caspase-3 in the HCPT-induced apoptotic process."
34294352
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"The induction of apoptosis by FAFs may act as a possible strategy for cancer chemotherapy."
23251241
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"Down-regulation of USP24 but not USP9X induces growth inhibition and apoptosis of T-ALL cells."
30911287
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"Because DASK1 , a Drosophila ortholog of ASK1, has been suggested to mediate Reaper -induced apoptosis, it is conceivable that faf might contribute to the induction of apoptosis through stabilizing ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20005844
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"Using human myeloid leukemia cells and a murine AML model, we find that genetic knockdown or pharmaceutical inhibition of USP9X inhibits leukemia cell proliferation, induces apoptosis, and delays AML development."
37454738
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"Whole-genome transcriptome analysis revealed that FAM induced up-regulation of apoptosis related genes and genes that encode for mediators of oxidative stress resistance and heat shock proteins."
28819274
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"The function of the UBX domain is not known, although the fragment of avian FAF‐1 containing the UBX domain causes apoptosis of transfected cells."
34516727
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"Usp9X knock-down causes MPNST cell death with variable caspase activation and features of apoptosis."
30478285
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"As with pharmacological inhibition of Usp9X activity, Usp9X knock-down produced biochemical features of apoptotic cell death including a significant loss in mitochondrial membrane potential (Fig. 2a–d)."
30478285
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"In a sepsis-induced AKI model, interference with Usp9x resulted in decreased levels of TLR4/NF-κB pathway-associated proteins, and reduced inflammatory cytokine release and apoptosis, thereby alleviating S-AKI."
38874156
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"USP9X PROMOTES LPS-INDUCED FIBROBLAST CELL APOPTOSIS, INFLAMMATION, AND OXIDATIVE STRESS BY REGULATION OF TBL1XR1 DEUBIQUITINATION."
39841820
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"Downregulation of USP9x by siRNA in LNCaP cells prevented Mcl-1 stabilization, increased apoptosis induction and reduced clonogenic survival following irradiation, particularly in LNCaP but to a lesser extent also in PC3 cells."
37173959
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"These results show that expression of USP9X is upregulated in hepatoma cells SMMC7721 and HepG2, and that downregulating USP9X by siRNA may induce cell apoptosis, inhibit cell growth and cell migration in the HCC SMMC7721 and HepG2 cell lines."
26171012
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"Knockdown of USP9X suppresses cell proliferation, inhibits G1/S phase conversion, and induces apoptosis in U251 and A172 cells."
27783990
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"USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3."
34112167
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"USP9X deficiency in HGC-27 and MKN-45 cells causes decreased proliferation, cell cycle arrest, extra apoptosis, and defective migration and invasion, which could be rescued by excessive MTH1."
39075342
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"Previous studies have suggested that deubiquitinase USP9X stabilizes myeloid cell leukemia sequence 1 (MCL1) and promotes tumor cell survival and apoptosis resistance [XREF_BIBR, XREF_BIBR]."
27783990
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"WP1130 is a small molecule that directly decreases the DUB activity of USP9X, which leads to the downregulation of MCL-1, ultimately facilitating apoptosis (63,64)."
37920433
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"It has been also reported that WP1130 blocks USP9X to promote apoptosis by sensitizing various solid tumor cells to ABT-737 and navitoclax (ABT-263), BH3 mimetics that inhibit anti-apoptotic Bcl-xL, Bcl-2, and Bcl-w [20,21]."
32050632
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"Knockdown of endogenous USP9X expression evidently inhibited the migration and invasion of PANC-1 cells, and promoted cell apoptosis."
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