IndraLab

Statements

USP9X activates apoptotic process. 15 / 16
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"As with pharmacological inhibition of Usp9X activity, Usp9X knock-down produced biochemical features of apoptotic cell death including a significant loss in mitochondrial membrane potential (Fig. 2a–d)."
30478285
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"Knockdown of endogenous USP9X expression evidently inhibited the migration and invasion of PANC-1 cells, and promoted cell apoptosis."
29130109
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"Previous studies have suggested that deubiquitinase USP9X stabilizes myeloid cell leukemia sequence 1 (MCL1) and promotes tumor cell survival and apoptosis resistance [XREF_BIBR, XREF_BIBR]."
27783990
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"Knockdown of USP9X suppresses cell proliferation, inhibits G1/S phase conversion, and induces apoptosis in U251 and A172 cells."
27783990
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"To correlate Tras-MMAE/FAM internalization with drug-induced apoptosis, cell viability was monitored using propidium iodide (PI) red fluorescence."
34522229
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"These results show that expression of USP9X is upregulated in hepatoma cells SMMC7721 and HepG2, and that downregulating USP9X by siRNA may induce cell apoptosis, inhibit cell growth and cell migration in the HCC SMMC7721 and HepG2 cell lines."
26171012
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"Usp9X knock-down causes MPNST cell death with variable caspase activation and features of apoptosis."
30478285
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"Down-regulation of USP24 but not USP9X induces growth inhibition and apoptosis of T-ALL cells."
30911287
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"Whole-genome transcriptome analysis revealed that FAM induced up-regulation of apoptosis related genes and genes that encode for mediators of oxidative stress resistance and heat shock proteins."
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"Specific knock-down of Usp9X induces apoptosis in glioblastoma cells."
26872380
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"USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3 ."
34112167
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"Expression levels of ARF-BP1 and Mule and Usp9x appears to be critical for the maintenance of proper cellular balance of anti- and pro apoptotic proteins, and contributes to cell sensitivity to apoptosis and is linked to tumor formation [XREF_BIBR, XREF_BIBR]."
21705204
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"USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3."
34112167
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"It has been also reported that WP1130 blocks USP9X to promote apoptosis by sensitizing various solid tumor cells to ABT-737 and navitoclax (ABT-263), BH3 mimetics that inhibit anti-apoptotic Bcl-xL, Bcl-2, and Bcl-w [20,21]."
32050632
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"siRNA knockdown of USP9X nearly completely suppressed apoptosis induced by cytokine treatment (XREF_FIG)."
26042473