IndraLab

Statements

WT1 decreases the amount of USP18. 6 / 6
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"A variety of subsequent, in vitro experiments consistently supported the notion that WT1 suppresses Usp18 expression, and we therefore conclude that Usp18 is a bona fide target for WT1 transcriptional regulatory function in the embryonic kidney."
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"Taken together our data demonstrate that Usp18 is a transcriptional target of WT1 and suggest that increased expression of USP18 following WT1 loss contributes to Wilms tumorigenesis."
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"These two independent experiments suggest that WT1 represses Usp18 expression in mammalian cells."
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"Taken together our data suggest that increased expression of USP18 following WT1 loss contributes to Wilms tumorigenesis."
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"Despite this increased expression, this truncated WT1 still was unable to repress the expression of the Usp18 reporter construct."
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"Cumulatively, these data indicate that WT1 (-KTS) down-regulates Usp18 expression via direct or indirect interaction with the Usp18 promoter."
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