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"Finally, trafficking inhibition activated UPR, and mature hERG channel degradation was increased by DHB."

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"DHB immediate perfusion inhibits hERG current concentration-dependently."

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"Furthermore, we also examined whether DHB inactivated hERG channel."

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"The results indicated that DHB inhibited the hERG channel by shortening the time constant of the onset of inactivation."

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"DHB treatment decreases hERG current but not hERG channel kinetics."

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"DHB acutely blocks hERG channel by binding to aromatic Tyr652 and Phe656 in S6 helix."

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"In our study, DHB inhibited the hERG current in a concentration dependent manner after immediate perfusion, and the IC 50 was 10.50 muM."

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"In the current study, we first demonstrated that DHB acutely blocked hERG channel by binding to the aromatic Tyr652 and Phe656."

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"In summary, we demonstrated that DHB directly blocked the hERG channel by binding to the aromatic Tyr652 and Phe656."

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"In conclusion, we demonstrated that DHB acutely blocked hERG channels by binding the aromatic Tyr652 and Phe656."

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